The NFC West running back landscape entering the 2025 season has some intriguing dynamics, particularly regarding the backup positions. Each of the four teams in the division—Arizona Cardinals, Los Angeles Rams, San Francisco 49ers, and Seattle Seahawks—maintains the same key backups from last year, creating a level of continuity that could either hinder or enhance their performance. Injuries and performance fluctuations among starters will likely dictate the impact of these second-string running backs.

Among the backups, players like Ty'Son Williams for the Cardinals and Kenneth Walker III from the Seahawks will be closely watched as potential breakout candidates. With the division being so competitive, the effectiveness of these backups could determine critical wins. Fantasy managers should keep an eye on their preseason performances and training camp reports as these might hint at their usage in the upcoming season.

With only 66 days remaining until the Arizona Cardinals' season opener against the New Orleans Saints on Sept. 7, the spotlight is on notable players who wore the number 66. This number has a rich history within the franchise, showcasing contributions from various athletes over the years.

Currently, offensive lineman McClendon Curtis, who joined the Cardinals after two seasons with the Seattle Seahawks, dons No. 66. Other players who have previously represented this number include Jackson Barton, Wyatt Davis, Josh Miles, Alameda Ta'amu, and Alan Faneca, among others. Each of these players left their mark, whether on the offensive line or the defensive front, contributing to the team's legacy.

Kyler Murray gears up for another NFL season, now entering his prime at 28. Over six seasons with the Arizona Cardinals, he has started 82 games, but a breakout season has eluded him. Despite being the first overall pick, annual expectations around his performance remain steady, yet average. His career stats are telling: QB rating, INT rate, TD percentage, sack percentage, and yards per attempt hover around league average.

In a perfect draft strategy for 12-team, single-quarterback, PPR leagues, prioritizing a top quarterback like Jayden Daniels can offer a substantial edge, allowing players to bolster their roster at other positions. Bijan Robinson stands out as a potential third overall pick, especially behind elite prospects like Ja'Marr Chase and Saquon Barkley. Robinson's performance in the latter half of 2024 established him as a strong fantasy asset, scoring an impressive 22.4 points per game.

Opting for a tight end early, such as Trey McBride, can solidify the roster further, as he delivered elite fantasy production last season. Continued improvements are expected with the same coaching staff returning. Further, securing high-upside players like Jahmyr Gibbs or Rashee Rice enhances the team’s depth, while ensuring a balanced approach across rounds will be critical.

Marvin Harrison Jr.'s rookie season fell short of expectations, finishing as WR30 despite high hopes for a top-20 finish. He showed flashes of potential with four touchdowns in a three-game stretch but struggled with uncatchable targets and chemistry with Kyler Murray. Improving that connection is essential for his fantasy value next season.

J.J. McCarthy, now the starting quarterback for the Minnesota Vikings, is set for success in a high-octane offense. With a talented supporting cast and a history of top quarterback performances, McCarthy has the potential to excel, especially considering the Vikings' offensive line improvements.

The 2024 NFL draft class has introduced several promising fantasy prospects, including Jayden Daniels and Malik Nabers. Conversely, Caleb Williams, now with the Chicago Bears, faces challenges in his rookie season, while Braelon Allen of the New York Jets looks to carve out a niche behind Breece Hall. Lastly, Trey Benson, the Arizona Cardinals' third-round pick, is in a prime position to become a valuable asset if James Conner falters.